Selected publications


Bartolomé, A , Ravusin, Y, Yu, J, Ferrante, AW, Pajvani, UB. (2022). An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak β Cell Mass Acquisition. Diabetes. (PMID: 35944274)

Featured in the journal cover!

Liang, J, Chirikjian, M, Pajvani, UB, Bartolomé, A . (2022). MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms. Biomolecules. 12(4)(PMID: 35454124)

Bartolomé, A , Suda, N, Yu, J, Zhu, C, Son, J, Ding, H, Califano, A, Accili, D, Pajvani, UB. (2022). Notch-mediated Ephrin signaling disrupts islet architecture and β cell function. JCI Insight. 7(6)(PMID: 35167496)

Bartolomé, A . (2022). Stem Cell-Derived β Cells: A Versatile Research Platform to Interrogate the Genetic Basis of β Cell Dysfunction. Int J Mol Sci. 23(1)(PMID: 35008927)


Yu, J, Zhu, C, Wang, X, Kim, K, Bartolome, A , Dongiovanni, P, Yates, KP, Valenti, L, Carrer, M, Sadowski, T, Qiang, L, Tabas, I, Lavine, JE, Pajvani, UB. (2021). Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis. Sci Transl Med. 13(599)(PMID: 34162749)

Bartolomé, A , Liang, J, Wang, P, Ho, DD, Pajvani, UB. (2021). Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex. Sci Rep. 11(1): 9803 (PMID: 33963249)

Bartolomé, A , Pajvani, UB. (2021). MTOR and Beta Cell Adaptation in T2D. J Clin Endocrinol Metab. 106(3): e1466-e1467 (PMID: 33274365)

Zhu, C, Ho, YJ, Salomao, MA, Dapito, DH, Bartolome, A , Schwabe, RF, Lee, JS, Lowe, SW, Pajvani, UB. (2021). Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features. J Hepatol. 74(3): 613-626 (PMID: 33038431)


Kanno, A, Asahara, SI, Furubayashi, A, Masuda, K, Yoshitomi, R, Suzuki, E, Takai, T, Kimura-Koyanagi, M, Matsuda, T, Bartolome, A , Hirota, Y, Yokoi, N, Inaba, Y, Inoue, H, Matsumoto, M, Inoue, K, Abe, T, Wei, FY, Tomizawa, K, Ogawa, W, Seino, S, Kasuga, M, Kido, Y. (2020). GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels. JCI Insight. 5(9)(PMID: 32376799)


Bartolome, A , Zhu, C, Sussel, L, Pajvani, UB. (2019). Notch signaling dynamically regulates adult β cell proliferation and maturity. J Clin Invest. 129(1): 268-280 (PMID: 30375986)


Zhu, C, Kim, K, Wang, X, Bartolome, A , Salomao, M, Dongiovanni, P, Meroni, M, Graham, MJ, Yates, KP, Diehl, AM, Schwabe, RF, Tabas, I, Valenti, L, Lavine, JE, Pajvani, UB. (2018). Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis. Sci Transl Med. 10(468)(PMID: 30463916)

Ravussin, Y, Edwin, E, Gallop, M, Xu, L, Bartolomé, A , Kraakman, MJ, LeDuc, CA, Ferrante, AW. (2018). Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding. Cell Metab. 28(2): 289-299.e5 (PMID: 29937378)


Bartolomé, A , García-Aguilar, A, Asahara, SI, Kido, Y, Guillén, C, Pajvani, UB, Benito, M. (2017). MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling. Mol Cell Biol. 37(23)(PMID: 28894028)
Featured in the journal cover!


Asahara, S, Etoh, H, Inoue, H, Teruyama, K, Shibutani, Y, Ihara, Y, Kawada, Y, Bartolome, A , Hashimoto, N, Matsuda, T, Koyanagi-Kimura, M, Kanno, A, Hirota, Y, Hosooka, T, Nagashima, K, Nishimura, W, Inoue, H, Matsumoto, M, Higgins, MJ, Yasuda, K, Inagaki, N, Seino, S, Kasuga, M, Kido, Y. (2015). Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c. Proc Natl Acad Sci U S A. 112(27): 8332-8337 (PMID: 26100882)


Bartolomé, A , Kimura-Koyanagi, M, Asahara, S, Guillén, C, Inoue, H, Teruyama, K, Shimizu, S, Kanno, A, García-Aguilar, A, Koike, M, Uchiyama, Y, Benito, M, Noda, T, Kido, Y. (2014). Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment. Diabetes. 63(9): 2996-3008 (PMID: 24740570

Bartolome, A , Guillén, C. (2014). Role of the mammalian target of rapamycin (mTOR) complexes in pancreatic β-cell mass regulation. Vitam Horm. 95: 425-469 (PMID: 24559928)


Bartolomé, A , López-Herradón, A, Portal-Núñez, S, García-Aguilar, A, Esbrit, P, Benito, M, Guillén, C. (2013). Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function. Biochem J. 455(3): 329-337 (PMID: 23981124)


Bartolome, A , Guillen, C, Benito, M. (2012). Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death. Autophagy. 8(12): 1757-1768 (PMID: 22951927)